In NATIONAL format, aka ITU-T Recommendation E123, the number is written (321) 204-4648
Likewise, in E123 INTERNATIONAL formal, it is written +1 321-204-4648
In E.164 standard format, the number is written +13212044648. E164 format is as per E123 INTERNATIONAL format but with no formatting applied.
In RFC3966 standard format, the number is written tel:+1-321-204-4648. FC3966 is as per INTERNATIONAL format, but with all spaces and other separating symbols replaced with a hyphen, and with any phone number extension appended with ";ext=". It also will have a prefix of "tel:" added .
To dial this number from within the United States, one would dial 1 (321) 204-4648
To dial this number from inside the United Kingdom or the European Union, one would dial 00 1 321-204-4648
Numbers like +13212044648 may be located in the America/New_York timezone, where the local time is currently Wednesday the 22nd of January 2020 06:18:35 AM.